[Creative PEGWorks 한국공식대리점] Cholesterol-PEG-DBCO

[Creative PEGWorks 한국공식대리점] Cholesterol-PEG-DBCO

[Cholesterol-PEG-DBCO]

Product Description:

Cholesterol-PEG-DBCO는 구리 이온이 없는 클릭 화학 반응에서 아지드와 반응합니다. 콜레스테롤은 세포막 구성 성분으로, 막 유동성, 탄성 및 투과성을 조절하는 독특한 기능을 수행합니다. 단백질이 막에 내포될 때 다른 지질 종의 배열로 인해 생성된 틈을 메웁니다. 양친매성 지질 유도체인 PEGylated cholesterol은 약물 전달 시스템으로서 리포좀 및 기타 미셀을 제조하는 데 사용될 수 있습니다. DBCO와 같은 기능군은 단백질, 항체, 염료 등 아지드 함유 모이어티를 미셀 또는 리포좀 표면에 접합하는 데 사용됩니다.

Properties:

• Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
• Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
• Density: PEG density is approximately 1.125 g/mL
• Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
• Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.

Product List:

• PLS-9977, Cholesterol-PEG-DBCO, MW 2k
• PLS-9978, Cholesterol-PEG-DBCO, MW 3.4k
• PLS-9979, Cholesterol-PEG-DBCO, MW 5k
• PLS-9970, Cholesterol-PEG-DBCO, MW 10k
• PLS-9976, Cholesterol-PEG-DBCO, MW 1k

 

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